molecular mechanism of isoniazid-induced mitochondrial toxicity

Isoniazid Toxicity

Pharmacokinetic characteristics of INH are presented. Adverse effects and toxicity caused by INH has been reviewed under the headings of neuropathy and seizures, hepatotoxicity, rhabdomyolysis, agranulocytosis, acidosis and other adverse drug reactions. Cases of poisoning by INH have been mentioned independently. Few case reports indicating symptoms of intoxication and the mechanism of toxicity...

Molecular toxicity mechanism of nanosilver.

Silver is an ancient antibiotic that has found many new uses due to its unique properties on the nanoscale. Due to its presence in many consumer products, the toxicity of nanosilver has become a hot topic. This review summarizes recent advances, particularly the molecular mechanism of nanosilver toxicity. The surface of nanosilver can easily be oxidized by O(2) and other molecules in the enviro...

molecular mechanism of metamphetamine toxicity in isolated rat liver mitochondria

Role of Mitochondrial Toxicity in BMS-986094-Induced Toxicity

method of glomerular filtration rate (clearance rate of the endogenous creatinine). Like low dose (11 mg/kg) of adefovir, low dose of tenofovir only also caused minor effects on the renal structure while higher doses of tenofovir caused severely gastrointestinal toxicity within 2 weeks. No renal toxicity was seen for either entecavir or telbivudine, highlighting a high degree of safety compared...

Effects of quercetin on bisphenol A-induced mitochondrial toxicity in rat liver

Objective(s): Recognized as a distinguished environmental and global toxicant, Bisphenol A (BPA) affects the liver, which is a vital body organ, by the induction of oxidative stress. The present study was designed to investigate the protective effect of quercetin against BPA in hepatotoxicity in Wistar rats and also, the activity of mitochondrial enzymes were evaluated...

Molecular mechanism of mitochondrial membrane fusion.

Mitochondrial fusion requires coordinated fusion of the outer and inner membranes. This process leads to exchange of contents, controls the shape of mitochondria, and is important for mitochondrial function. Two types of mitochondrial GTPases are essential for mitochondrial fusion. On the outer membrane, the fuzzy onions/mitofusin proteins form complexes in trans that mediate homotypic physical...